Acrodermatitis enteropathica (ADE) is an uncommon, inherited disorder occurring due to defective Zinc absorption. It can occur as an acquired condition secondary to impaired intestinal absorption in a wide variety of clinical conditions or due to nutritional deficiency. It is clinically characterized by triad of acral dermatitis, alopecia and diarrhoea. Acrodermatitis enteropathica is also called acrodermatitis enteropathy, primary zinc malabsorption syndrome, Danbolt-Closs syndrome and Brandt syndrome [6-8]. What is the role of zinc in the body? Zinc is an essential micronutrient with better bioavailability from human milk than cow's milk or other infant formulae. Acrodermatitis enteropathica is generally caused by an autosomal recessive mutation of the SLC39A4 gene located on chromosome 8q24.3, which is the gene responsible for zinc transportation. 2 Being hereditary in nature, almost all cases occur in the pediatric population, causing malabsorption of the essential mineral zinc. 3 Although rare Acrodermatitis enteropathica, zinc sulphate, elemental zinc. Introduction Acrodermatitis enteropathica (AE) is a rare inherited disorder transmitted as an autosomal recessive trait. The clinical syndrome is characterized by basic triad of acral dermatitis, alopecia and diarrhea. The distribution of scaly and vesicobullous rash Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (542K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Therefore, we analyzed available information from dietary zinc depletion studies and case reports of acrodermatitis enteropathica (AE) to establish the relation between PZC and clinical evidence of zinc deficiency and to further assess the utility of PZC as a biomarker of zinc nutrition. Acrodermatitis Enteropathica There are three forms of this condition, two acquired forms and an inborn form that is apparent at birth (congenital). The acquired forms can be caused a deficiency of zinc in the diet. In the congenital form, there appears to be a deficiency or Acrodermatitis enteropathica (AE) was diagnosed in 2 siblings, boy and girl, at the age of 10 and 6 weeks. The family history is unremarkable except for consanguinity 5 generations previously. The clinical symptoms of the 2 patients conformed to the known features of AE, the gastrointestinal involvement loosing its significance with increasing age. With Acrobat Reader DC, you can do more than just open and view PDF files. It's easy to add annotations to documents using a complete set of commenting tools. View and annotate PDF files. Acrodermatitis enteropathica is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea. It is caused by mutations in the gene that encodes a membrane protein that binds zinc. We report a 14-month-old boy, admitted for erythematous, scaly and Acrodermatitis Enteropathica (AE) is a rare inherited metabolic condition that affects zinc absorption and inheritance is often seen in an autosomal recessive pattern . The frequency of inherited cases is estimated at 1:500,000 individuals with no obvious correlation in race or gender [ 2 ]. Acrodermatitis enteropathica has been recognized as a rare clinical entity distinct from epidermolysis bullosa dystrophica since 1942, when Da