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It's best to apply Bio-Clean when drains won't be used for 6 to 8 hours. (at bedtime for example) Apply Bio-Clean to each drain for 5 consecutive days to clean A usage guide to Bio-Clean drain cleaner. Mixing Bio-Clean with warm water works best. Detailed Home & Commercial Applications Manual (pdf). The instructions to use Bio-clean are provided with every container. For best results Bio-clean should be mixed with warm water and thrown down the drain. Mix 2 tablespoons of Bio-Clean with 1 quart of warm water for 5 straight days. Then mix 2 tablespoons of Bio-Clean with 1 quart of warm water and treat once a week after the initial 5 day treatment. Mix 2 tablespoons of Bio-Clean with 1 quart of warm water for 5 straight days. It is hurled there by the high speed rotating blades. By following BIO-CLEAN instructions this waste will be quickly digested by the live cultures, thus eliminating Environmental Plumbing Ottawa is a Plumbing company setup by expert Gary Greco. Over 35 years of local experience, we offer expert drain cleaning, plumbing Application Instructions. BIO-CLEAN should be mixed with warm (not hot) water vigorously for 30 seconds then applied when no water will be drained for six to