Background —Corticotropin-releasing hormone (CRH) plays a key role in modulating intestinal motility in stressed animals. Aims —To evaluate the effect of CRH on intestinal motility in humans and to determine whether patients with irritable bowel syndrome (IBS) have an exaggerated response to CRH. The CRH stimulation test can help a doctor determine what is causing a drop or rise in a patient's adrenal hormones. CRH (corticotropin-releasing hormone) is a naturally-occurring hormone which causes the pituitary gland to secrete the hormone ACTH. Corticotropin releasing factor (CRF)-stimulation test in normal controls and patients with disturbances of the hypothalamo-pituitary-adrenal axis. Muller OA, Dorr HG, Hagen B, Stalla GK, von Werder K. Corticotropin-releasing hormone (CRH), also called corticotropin-releasing factor (CRF), is a peptide hormone that activates the synthesis and release of adrenocorticotropic hormone (ACTH) from Corticotropin-releasing hormone (CRH), originally named corticotropin-releasing factor (CRF), and also called corticoliberin, is a polypeptide hormone and neurotransmitter involved in the stress response.. Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. Corticotropin-releasing factor (CRF), the key neuropeptide in the stress cascade, has major inhibitory actions on testicular function in addition to its known antireproductive effects at the central level (inhibition of sexual behavior and LH We gave a standard dexamethasone suppression test and an ovine corticotropin-releasing hormone (CRH) stimulation test to 41 patients with adrenocorticotrophic hormone (ACTH)-dependent hypercortisolism to determine the efficacy of each test in the differential diagnosis of Cushing's syndrome. Human corticotropin-releasing factor plus lysine-vasopressin test during glucocorticoid therapy Article (PDF Available) in Journal of Clinical Investigation 82(1):13-6 · August 1988 with 16 Reads Original Article from The New England Journal of Medicine — The Corticotropin-Releasing Factor Stimulation Test — An Aid in the Evaluation of Patients with Cushing's Syndrome logo-32 logo-40 corticotropin-releasing factor: a factor secreted by the hypothalamus that stimulates the pituitary to release adrenocorticotropic hormone. Synonym(s): corticotropin-releasing factor M.O. Huising, W.W. Vale, in Encyclopedia of Neuroscience, 2009. Corticotropin-releasing factor (CRF) is the most potent hypothalamic neuropeptide to induce the release of adrenocorticotropic hormone from the anterior pituitary gland, initiating a cascade of endocrine events collectively known as the neuroendocrine stress response. injection of a corticotropin releasing hormone (CRH) followed by a series of blood sampling. The purpose of this test is to help us to find out if your pituitary gland is causing an imbalance of steroid hormones in your body, known as Cushing's disease. Preparation for the test •ou should not eat anything from 11pm the night before your test. Y injection of a corticotropin releasing hormone (CRH) followed by a series of blood sampling. The purpose of this test is to help us to find out if your pituitary gland is causing an imbalance of steroid hormones in your body, known as Cushing's disease. Preparation for the test •ou should not eat anything from 11pm the night before your test. Y