Drug induced hepatotoxicity Hepatotoxicity implies chemical-driven liver damage. Liver injury may be produced by a large variety of chemical substances The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents Certain medicinal agents, when Guidance for Industry: Drug-Induced Liver Injury: Premarketing Clinical Evaluation [PDF](U.S. Department of Health of Human Services, FDA, Center for Drug Evaluation and Research, Center Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver (Zimmerman, 2nd ed. ACETAMINOPHEN-INDUCED HEPATOTOXICITY. Laura P. James, Philip R. Mayeux and Jack A. Hinson. He is the editor of Drug Metabolism Reviews and is on the editorial boards of Toxicology and Applied Pharmacology and the Journal of Toxicology and Environmental Health. Drug-induced hepatotoxicity. ?Close. Not in Library. 1 2 3 4 5. Want to Read. Are you sure you want to remove Drug-induced hepatotoxicity from your list? Drug-Induced Hepatotoxicity: Metabolic, Genetic and Immunological Basis Dolores B. Njoku Departments of Abstract: Drug-induced hepatotoxicity is a significant cause of acute liver failure and is usually the primary reason that therapeutic drugs are removed from the commercial market. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. The manifestations of drug-induced 4. Mechanism of Drug Induced Steatosis and Steatohepatitis. Hepatic steatosis is characterized by accumulation of intrahepatocytes triglycerides-esters Liver histology of a patient with MTX induced hepatotoxicity demonstrating macro and microvesicular steatosis, hepatocellular ballooning, and Keywords drug-induced liver injury; adverse drug reactions; pre-clinical assays; information theory; partial least-squares modeling INTRODUCTION NIH-PA Author Manuscript Idiosyncratic drug hepatotoxicity is defined as drug-induced liver injury that occurs in a very small fraction of human Drug-induced liver injury (DILI) is a critical issue in drug development because DILI causes failures in A performance comparison using different thresholds can be found in Additional file 2: Figure S1-S2. The role of metabolic activation in drug-induced hepatotoxicity. Annu Rev Pharmacol Toxicol. Idiosyncratic hepatotoxicity is more likely a series of rare drug-related toxicities with different forms of pathogenesis than a single entity. There are 2 main categories of idiosyncratic hepatotoxicity recognized in humans: hypersensitivity-related drug-induced liver injury (drug allergy) and toxic Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. @inproceedings{Abbott2017ColchicineInducedH, title={Colchicine-Induced Hepatotoxicity}, author={Collette E. Abbott and Ruliang Xu and Samuel H Drug-induced liver injury (DILI) is an important cause of morbidity and mortality. DILI can even cause acute liver failure and the need for liver tran Hepatotoxicity Modeling Using Counter-Propagation Artificial Neural Networks: Handling an Imbalanced Classification Problem. Drug-induced liver injury (DILI) is an important cause of morbidity and mortality. DILI can even cause acute liver