Nasopharyngeal carcinoma is a head and neck cancer with a specific geographic distribution. It affected an estimated 130,000 patients worldwide in 2018, with the highest rates occurring in regions in South China, Southeastern Asia, and North Africa.1 More than 70% of patients receive a diagnosis of Nasopharyngeal carcinoma ABU SUFIAN HASSAN AHMED EL HAJ (E.N.T. Consultant) Associate Professor Department of Surgery Faculty of Medicine, University of Gezira ANATOMY ANATOMY Introduction The Nasopharynx has a cuboidal shape, the lateral walls are formed by the Eustachian Nasopharyngeal carcinoma is a rare type of head and neck cancer. It starts in the upper part of your throat, behind the nose. This area is called the nasopharynx. Thus, there is a need to conduct secondary prevention, such as improving rates of early detection, early diagnosis, and early Nasopharyngeal carcinoma (NPC) is an epithelial malignant tumor which arises from the mucosa of the nasopharyngeal cavity. Diagnosis is based on histopathological examination of the biopsied tissue obtained through endoscopy of the nasopharynx. Nasopharyngeal carcinoma (NPC) is an endemic disease that is epidemic in areas of Southeast Asia, Southern China, Hong Kong, and Taiwan [1]. In 1978 The diagnoses of NPC mainly depend on the endoscopic examination and histological observation of biopsies and often present later-stage disease. Early diagnosis is critical to reduce the mortality caused by nasopharyngeal carcinoma (NPC). MicroRNAs (miRNAs) are dysregulated and play important roles in carcinogenesis. Therefore, this study aimed to identify diagnostically relevant circulating miRNA signatures in patients with NPC. Carcinoma of the nasopharynx accounts for less than 1% of all childhood cancers (1) and children aged between 10 and 19 years are the most common When evaluating significant masses in the posterior nasopharynx, the age of the pediatric patient is an important consideration in narrowing the Nasopharyngeal carcinoma arises in the lining of the nasal cavity and pharynx, and it accounts for Nasopharyngeal carcinoma in children and adolescents in an endemic area: a report of 185 cases. A diagnosis can be made from a biopsy of the primary tumor or enlarged lymph nodes of the neck. Eighty-four patients diagnosed with nasopharyngeal carcinoma between 1972 and 2002 were retrospectively evaluated. There were 51 males and 33 females with a median age of 13 years (7-17) at diagnosis. At the time of diagnosis, 78.5% of the patients were at advanced stage (stages III and Nasopharyngeal carcinoma detection by tissue smears using surface-enhanced Raman spectroscopy. Spectroscopy Letters, Vol. 50, Issue. Potential factors associated with clinical stage of nasopharyngeal carcinoma at diagnosis: a case-control study. Chinese Journal of Cancer, Vol. 36 D00 Carcinoma in situ of oral cavity, oesophagus and stomach D01 Carcinoma in situ of other and unspecified iZ00 General examination and investigation of persons without complaint and reported diagnosis iiZ01 Other Floor of nasopharynx Nasopharyngeal (anterior) (posterior) surface of soft D00 Carcinoma in situ of oral cavity, oesophagus and stomach D01 Carcinoma in situ of other and unspecified iZ00 General examination and investigation of persons without complaint and reported diagnosis iiZ01 Other Floor of nasopharynx Nasopharyngeal (anterior) (posterior) surface of soft Nasopharyngeal car