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Pharmacology and mechanism of action of pemetrexed. Pemetrexed is a novel multitargeted antifolate that inhibits > or = 3 enzymes involved in folate metabolism and purine and pyrimidine synthesis. These enzymes are thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. 146. Based on its mechanism of action, ALIMTA can cause fetal harm when administered to a pregnant woman. Pemetrexed. 147 administered intraperitoneally ALIMTA (pemetrexed for injection), for Intravenous Use Based on findings from animal studies and its mechanism of action, ALIMTA can cause fetal harm Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target. pemetrexed. COMMON TRADE NAME(S): Alimta® back to top. B - Mechanism of Action and Pharmacokinetics. Pemetrexed is a pyrrolopyrimidine antifolate that Jul 1, 2011 - drug substance and based on batch analysis and stability data of pemetrexed lots pemetrexed, which is considered acceptable, as the mechanism of action Feb 1, 2007 - Oct 2, 2007 -Pemetrexed is a novel multitargeted antifolate that inhibits ? 3 enzymes involved in folate metabolism and purine and pyrimidine synthesis. These enzymes are