A STUDY OF FLUIDISED BED GRANULATION A thesis submitted for the degree of Ph.D. in the Uni versity of London by Peter Geoffrey Smith B.Sc. (Eng.) February 1980 Ramsay Laboratory of Chemical Engineering University College London this type of granulation, the formation and agglomeration of granules depend on the properties of the binder, particularly the type of binder and the concentration of the solution. Process parameters also are important, but they are not as critical as those for granulating with water as the spray medium. [10-13] Granulation with water (Instantizing) This process is similar to granulation with Melt Granulation Here granulation is achieved by the addition of meltablebinder. Binder is in solid state at room temperature but melts inthe temperature range of 50 - 80?C. Melted binder then acts like a binding liquid. There is no need of drying phase since dried granules areobtained by cooling it to room temperature.1/27/2013 SATARA Au cours du processus de granulation, differents types de cellule sont impliques : les fibroblastes permettent de refermer la plaie, les angioblastes permettent la formation de nouveaux capillaires et les keratinocytes permettent l'epithelialisation du tissu. Les signaux des macrophages permettent de coordonner ces processus. Both designs are excellently suited for integration in a granulation line. Glatt offers a truly unique benefit with the PRO design: all the components of a granulation line (vertical granulator, sieves, pneumatic conveyance and fluid bed) are available in a 12 bar pressure-shock resistant design. This eliminates any discussion Granulation method can be broadly classified into two types: Wet granulation and Dry granulation. Wet Granulation. The most widely used process of agglomeration [1-7] in pharmaceutical industry is wet granulation. Wet granulation process simply involves wet massing [8-15] of the powder blend with a granulating liquid, wet sizing and drying. Granulation methods can be divided into two types: wet methods (wet granulation) : use a liquid in the process, binders are added in solution/suspension form ; dry methods (dry granulation/slugging) : no liquid is used. In a suitable formulation a number of different excipients will be needed in addition to the drug. The common types used are Granulation method can be broadly classified into two types: Wet granulation and Dry granulation. Wet Granulation The most widely used process of agglomeration [1-7] in pharmaceutical industry is wet granulation. Wet granulation process simply involves wet massing [8-15] of the powder blend with a granulating liquid, wet sizing and drying. Important steps involved in the wet granulation i PARTICLE GROWTH AND AGGLOMERATION PROCESSES R. P. J. Sochon and A.D. Salman Particle Products Group, Department of Chemical and Process Engineering, University of Sheffield, UK Keywords: Granulation, Size-enlargement, Nucleation, Growth, Coalescence, Breakage, Powder Contents 1. Introduction 2. Product properties 3. Rate processes 3.1. Wetting gmpua.com Diagram: Wet granulation in vertical granulator Powder Aqueous or organic binder N 2 before addition of organic binder n 2 n 1 Production of solid particles from powder. In wet granulation, powder is charged into a VG working vessel and the product is vig-orously mixed by an agitator and a chopper. Mixing continues while it is then wetted or Read the latest chapters of Handbook of Powder Technology at ScienceDirect.com, Elsevier's leading