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The recommended dose is either 500 mg PO once daily for 3 days (e.g., Zithromax Tri-Pak) or 500 mg PO on first day of therapy, followed by 250 mg PO once Azithromycin is used to treat a variety of infections. 500 mg intravenously (IV) as single dose for at least 2 days; follow with oral therapy with single dose of 500 Medscape - Infection-specific dosing for Zithromax (azithromycin), frequency-based 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5 Mar 27, 2020 - The safety of re-dosing azithromycin in pediatric patients who vomit after receiving 30 mg/kg as a single dose has not been established. In clinical studies involving May 15, 2019 - May 2, 2019 - Zithromax is most familiar to the public as the “Z-Pak,” a convenient five-day pill regimen with a dose of 500 mg (2 tablets of 250 mg) the first day and 250 mg for Zithromax is most familiar to the public as the “Z-Pak,” a convenient five-day pill regimen with a dose of 500 mg (2 tablets of 250 mg) the first day and 250 mg for